154563-54-9
154563-54-9 structure
- Name: SP 100030
- Chemical Name: SP-100030
- CAS Number: 154563-54-9
- Molecular Formula: C14H5ClF9N3O
- Molecular Weight: 437.65
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2021-01-07 17:22:50
- Modify Date: 2024-01-19 20:20:25
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SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA)[1][2].
| Name | SP-100030 |
|---|
| Description | SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA)[1][2]. |
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| Related Catalog | |
| In Vitro | SP-100030 blocks the production of IL-2 and IL-8 in Jurkat T-cells at the same concentrations as seen in the luciferase assay (IC50≈30 nM)[1]. ELISA and RT-PCR confirmed that IL-2, IL-8, and TNF-alpha production by activated Jurkat and other T cell lines were inhibited by SP100030[2]. |
| In Vivo | SP100030 (10 mg/kg/day; i.p.; day 21 to day 34) significantly decreased arthritis severity[2]. Animal Model: Six- to 8-wk-old male DBA/1J mice (immunized with type II collagen)[2] Dosage: 10 mg/kg Administration: I.p.; daily, starting at day 21 to the end of the study on day 34 Result: Significantly decreased arthritis scores compared with controls; Histologic evaluation of the paws from mice treated from day 20 to 34 showed a trend toward decreased inflammation. |
| References |
| Molecular Formula | C14H5ClF9N3O |
|---|---|
| Molecular Weight | 437.65 |