Shanghai Nianxing Industrial Co., Ltd
China
Product Name: UNC926hydrochloride
Price: Check
Purity: 98.71%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: UNC926 hydrochloride
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

1782573-49-2

1782573-49-2 structure

1782573-49-2 structure

Name: UNC 926 hydrochloride
Chemical Name: UNC926 hydrochloride
CAS Number: 1782573-49-2
Molecular Formula: C₁₆H₂₂BrClN₂O
Molecular Weight: 373.72
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2021-01-09 18:09:03
Modify Date: 2025-08-26 11:06:10
UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM[1].

Name	UNC926 hydrochloride

Description	UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	IC50: 3.9 μM (L3MBTL1), 3.2 μM (L3MBTL3), 15.6 μM (L3MBTL4)[1]
In Vitro	UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7[1]. UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1[1].
References	[1]. Herold JM, et al. Structure-activity relationships of methyl-lysine reader antagonists. MedChemComm. 2012;3(45):45-51.

Molecular Formula	C₁₆H₂₂BrClN₂O
Molecular Weight	373.72

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