1782573-49-2
1782573-49-2 structure
- Name: UNC 926 hydrochloride
- Chemical Name: UNC926 hydrochloride
- CAS Number: 1782573-49-2
- Molecular Formula: C16H22BrClN2O
- Molecular Weight: 373.72
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2021-01-09 18:09:03
- Modify Date: 2024-01-16 17:18:42
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UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM[1].
| Name | UNC926 hydrochloride |
|---|
| Description | UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 3.9 μM (L3MBTL1), 3.2 μM (L3MBTL3), 15.6 μM (L3MBTL4)[1] |
| In Vitro | UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7[1]. UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1[1]. |
| References |
| Molecular Formula | C16H22BrClN2O |
|---|---|
| Molecular Weight | 373.72 |