1207064-61-6

1207064-61-6 structure

Name: WAY208466 dihydrochloride
Chemical Name: WAY 208466 dihydrochloride
CAS Number: 1207064-61-6
Molecular Formula: C₁₇H₂₀Cl₂FN₃O₂S
Molecular Weight: 420.329
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2021-01-10 15:34:15
Modify Date: 2024-01-12 12:21:54
WAY 208466 dihydrochloride is a potent and selective 5-HT6 receptor agonist (EC50=7.3 nM for the human 5-HT6 receptor). WAY-208466 dihydrochloride elevates cortical GABA levels in rat frontal cortex[1]. WAY 208466 dihydrochloride exhibits antidepressant and anxiolytic-like effects[2].

Name	WAY 208466 dihydrochloride
Synonyms	MFCD20926423 2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-1-yl}-N,N-dimethylethanamine dihydrochloride WAY 208466 dihydrochloride WAY-208466 (hydrochloride) 1H-Pyrrolo[2,3-b]pyridine-1-ethanamine, 3-[(3-fluorophenyl)sulfonyl]-N,N-dimethyl-, hydrochloride (1:2) WAY-208466 DIHYDROCHLORIDE

Description	WAY 208466 dihydrochloride is a potent and selective 5-HT6 receptor agonist (EC50=7.3 nM for the human 5-HT6 receptor). WAY-208466 dihydrochloride elevates cortical GABA levels in rat frontal cortex[1]. WAY 208466 dihydrochloride exhibits antidepressant and anxiolytic-like effects[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Schechter LE, et al. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. [2]. Carr GV, Schechter LE, Lucki I. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacology (Berl). 2011 Feb;213(2-3):499-507.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport