1246030-96-5

1246030-96-5 structure

Name: GSK 2250665A
Chemical Name: trans-4-({4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]-2-pyrimidinyl}amino)cyclohexanol
CAS Number: 1246030-96-5
Molecular Formula: C₂₆H₂₉N₅OS
Molecular Weight: 459.606
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Itk
Create Date: 2021-01-09 16:35:11
Modify Date: 2025-09-03 19:48:30
GSK-2250665A (Compound 13) is a selective Itk inhibitor with a pKi of 9.2.

Name	trans-4-({4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]-2-pyrimidinyl}amino)cyclohexanol
Synonyms	trans-4-({4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]-2-pyrimidinyl}amino)cyclohexanol Cyclohexanol, 4-[[4-[(6-ethyl-2-benzothiazolyl)amino]-6-(phenylmethyl)-2-pyrimidinyl]amino]-, trans-

Description	GSK-2250665A (Compound 13) is a selective Itk inhibitor with a pKi of 9.2.
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Itk
In Vitro	GSK-2250665A (Compound 13) achieves a pIC50 of 7.3 in the cell assay, measuring inhibition of IFNγ production from PBMCs (Peripheral Blood Mononuclear Cells) [1].
References	[1]. Alder CM, et al. Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy. ACS Med Chem Lett. 2013 Aug 12;4(10):948-52.