1382477-96-4

1382477-96-4 structure

Name: MpsBAY2a
Chemical Name: N-Cyclopropyl-4-[8-(isobutylamino)-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide
CAS Number: 1382477-96-4
Molecular Formula: C₂₉H₂₈N₆O
Molecular Weight: 476.572
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2021-01-08 18:40:34
Modify Date: 2024-01-11 18:22:53
Mps-BAY2a is a monopolar spindle 1 (MPS1) inhibitor with an IC50 of 1 nM against human MPS1. Mps-BAY2a induces mitotic aberrations and apoptosis in cancer cells[1].

Name	N-Cyclopropyl-4-[8-(isobutylamino)-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide
Synonyms	MFCD29081183 N-Cyclopropyl-4-[8-(isobutylamino)-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide Benzamide, N-cyclopropyl-4-[8-[(2-methylpropyl)amino]-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]-

Description	Mps-BAY2a is a monopolar spindle 1 (MPS1) inhibitor with an IC50 of 1 nM against human MPS1. Mps-BAY2a induces mitotic aberrations and apoptosis in cancer cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Mps1 Signaling Pathways >> Cell Cycle/DNA Damage >> Mps1
Target	IC50: 1 nM (human MPS1), 2.6 nM (rat MPS1), 9 nM (mouse MPS1)[1]
References	[1]. Jemaà M, et al. Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ. 2013 Nov;20(11):1532-45.