MpsBAY2a

Modify Date: 2024-01-11 18:22:53

MpsBAY2a Structure
MpsBAY2a structure
Common Name MpsBAY2a
CAS Number 1382477-96-4 Molecular Weight 476.572
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C29H28N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MpsBAY2a


Mps-BAY2a is a monopolar spindle 1 (MPS1) inhibitor with an IC50 of 1 nM against human MPS1. Mps-BAY2a induces mitotic aberrations and apoptosis in cancer cells[1].

 Names

Name N-Cyclopropyl-4-[8-(isobutylamino)-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide
Synonym More Synonyms

 MpsBAY2a Biological Activity

Description Mps-BAY2a is a monopolar spindle 1 (MPS1) inhibitor with an IC50 of 1 nM against human MPS1. Mps-BAY2a induces mitotic aberrations and apoptosis in cancer cells[1].
Related Catalog
Target

IC50: 1 nM (human MPS1), 2.6 nM (rat MPS1), 9 nM (mouse MPS1)[1]

References

[1]. Jemaà M, et al. Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ. 2013 Nov;20(11):1532-45.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C29H28N6O
Molecular Weight 476.572
Exact Mass 476.232452
LogP 5.34
Index of Refraction 1.716

 Synonyms

MFCD29081183
N-Cyclopropyl-4-[8-(isobutylamino)-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide
Benzamide, N-cyclopropyl-4-[8-[(2-methylpropyl)amino]-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]-