Chemical Name: 3-[(3-chlorophenoxy)methyl]-1-tetrahydropyran-4-yl-pyrazolo[3,4-d]pyrimidin-4-amine;hydrochloride
CAS Number: 1391052-28-0
Molecular Formula: C17H19Cl2N5O2
Molecular Weight: 396.271
Create Date: 2021-01-09 18:19:29
Modify Date: 2024-10-05 20:08:40
PF-4800567 hydrochloride is a casein kinase 1e (CK1e) selective inhibitor (IC50 = 32 nM) that is 20 fold selective for the CK1e isoform over CK1d. PF-4800567 blockes CK1e-mediated PER3 nuclear translocation, but does not effect the circadian clock in animal studies.
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