1414248-06-8
1414248-06-8 structure
- Name: SR 1903
- Chemical Name: SR 1903
- CAS Number: 1414248-06-8
- Molecular Formula: C27H27F6N3O
- Molecular Weight: 523.513
- Create Date: 2021-01-13 19:33:01
- Modify Date: 2025-08-23 19:25:41
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SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-1903 reduces the severity of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.
| Name | SR 1903 |
|---|---|
| Synonyms |
SR 1903
1,1,1,3,3,3-Hexafluoro-2-(2'-methyl-4'-{[4-(4-pyridinylmethyl)-1-piperazinyl]methyl}-4-biphenylyl)-2-propanol [1,1'-Biphenyl]-4-methanol, 2'-methyl-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)- |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 559.0±50.0 °C at 760 mmHg |
| Molecular Formula | C27H27F6N3O |
| Molecular Weight | 523.513 |
| Flash Point | 291.9±30.1 °C |
| Exact Mass | 523.205811 |
| LogP | 4.74 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.550 |