1897379-34-8

1897379-34-8 structure

Name: SLM 6031434 hydrochloride
Chemical Name: SLM6031434 (hydrochloride)
CAS Number: 1897379-34-8
Molecular Formula: C₂₂H₃₁ClF₃N₅O₂
Molecular Weight: 489.96
Catalog: Signaling Pathways Immunology/Inflammation SPHK
Create Date: 2021-01-02 10:30:27
Modify Date: 2025-08-27 13:50:04
SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research[1][2].

Name	SLM6031434 (hydrochloride)
Synonyms	SLM6031434 (hydrochloride) (2S)-2-{3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-pyrrolidinecarboximidamide hydrochloride (1:1) 1-Pyrrolidinecarboximidamide, 2-[3-[4-(octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-, (2S)-, hydrochloride (1:1)

Description	SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> SPHK
References	[1]. Yugesh Kharel, et al. Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. J Pharmacol Exp Ther. 2015 Oct;355(1):23-31.