SLM 6031434 hydrochloride

Modify Date: 2025-08-27 13:50:04

SLM 6031434 hydrochloride Structure
SLM 6031434 hydrochloride structure
 Common Name SLM 6031434 hydrochloride
CAS Number 1897379-34-8 Molecular Weight 489.96
Density N/A Boiling Point N/A
Molecular Formula C22H31ClF3N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SLM 6031434 hydrochloride


SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research[1][2].

 Names

Name SLM6031434 (hydrochloride)
Synonym More Synonyms

 SLM 6031434 hydrochloride Biological Activity

Description SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research[1][2].
Related Catalog
References

[1]. Yugesh Kharel, et al. Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. J Pharmacol Exp Ther. 2015 Oct;355(1):23-31.

 Chemical & Physical Properties

Molecular Formula C22H31ClF3N5O2
Molecular Weight 489.96
Exact Mass 489.211853

 Synonyms

SLM6031434 (hydrochloride)
(2S)-2-{3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-pyrrolidinecarboximidamide hydrochloride (1:1)
1-Pyrrolidinecarboximidamide, 2-[3-[4-(octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-, (2S)-, hydrochloride (1:1)
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