2226393-62-8

2226393-62-8 structure

Name: Photoswitchable PAD inhibitor
Chemical Name: N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-[(E)-phenyldiazenyl]benzamide
CAS Number: 2226393-62-8
Molecular Formula: C₂₆H₂₆ClN₇O
Molecular Weight: 487.984
Create Date: 2021-01-09 20:09:43
Modify Date: 2024-02-04 19:34:52
Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity. Without photoactivation, it is a weak inhibitor of PAD2 and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro. It does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination.

Name	N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-[(E)-phenyldiazenyl]benzamide
Synonyms	Benzamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-4-[(E)-2-phenyldiazenyl]- N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-[(E)-phenyldiazenyl]benzamide