Photoswitchable PAD inhibitor
Modify Date: 2024-02-04 19:34:52
Photoswitchable PAD inhibitor structure
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Common Name | Photoswitchable PAD inhibitor | ||
|---|---|---|---|---|
| CAS Number | 2226393-62-8 | Molecular Weight | 487.984 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C26H26ClN7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Photoswitchable PAD inhibitorPhotoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity. Without photoactivation, it is a weak inhibitor of PAD2 and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro. It does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination. |
| Name | N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-[(E)-phenyldiazenyl]benzamide |
|---|---|
| Synonym | More Synonyms |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C26H26ClN7O |
| Molecular Weight | 487.984 |
| Exact Mass | 487.188751 |
| LogP | 4.19 |
| Index of Refraction | 1.672 |
| Benzamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-4-[(E)-2-phenyldiazenyl]- |
| N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-[(E)-phenyldiazenyl]benzamide |