714240-31-0

714240-31-0 structure

Name: NCGC00029283
Chemical Name: 3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-quinolin-2-ol
CAS Number: 714240-31-0
Molecular Formula: C₁₈H₁₂FN₃O₃
Molecular Weight: 337.305
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2021-01-16 00:29:39
Modify Date: 2024-01-11 10:49:59
NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1].

Name	3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-quinolin-2-ol
Synonyms	2(1H)-Quinolinone, 3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy- 3-[5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy-2(1H)-quinolinone 3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-quinolin-2-ol

Description	NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1]. Cell Proliferation Assay[1] Cell Line: U2-OS cells Concentration: 1 μM, 10 μM, 100 μM Incubation Time: 24 h, 48 h, 72 h Result: Showed a reduction in U2-OS cell proliferation.
References	[1]. Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019 Jan 9;14(1):e0210525.

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