NCGC00029283
Modify Date: 2024-01-11 10:49:59
NCGC00029283 structure
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Common Name | NCGC00029283 | ||
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| CAS Number | 714240-31-0 | Molecular Weight | 337.305 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 576.7±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H12FN3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 302.6±32.9 °C | |
Use of NCGC00029283NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1]. |
| Name | 3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-quinolin-2-ol |
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| Synonym | More Synonyms |
| Description | NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1]. |
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| Related Catalog | |
| In Vitro | NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1]. Cell Proliferation Assay[1] Cell Line: U2-OS cells Concentration: 1 μM, 10 μM, 100 μM Incubation Time: 24 h, 48 h, 72 h Result: Showed a reduction in U2-OS cell proliferation. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 576.7±60.0 °C at 760 mmHg |
| Molecular Formula | C18H12FN3O3 |
| Molecular Weight | 337.305 |
| Flash Point | 302.6±32.9 °C |
| Exact Mass | 337.086273 |
| LogP | 5.61 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.647 |
| Hazard Codes | Xi |
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| 2(1H)-Quinolinone, 3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy- |
| 3-[5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy-2(1H)-quinolinone |
| 3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-quinolin-2-ol |