1375752-78-5
1375752-78-5 structure
- Name: BMS-984923
- Chemical Name: BMS-984923
- CAS Number: 1375752-78-5
- Molecular Formula: C22H15ClN2O2
- Molecular Weight: 374.82
- Create Date: 2021-01-10 10:49:06
- Modify Date: 2024-01-01 21:42:43
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BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling.
| Name | BMS-984923 |
|---|
| Description | BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling. |
|---|
| Molecular Formula | C22H15ClN2O2 |
|---|---|
| Molecular Weight | 374.82 |