146662-42-2

146662-42-2 structure

Name: SR 2640 hydrochloride
Chemical Name: SR 2640 hydrochloride
CAS Number: 146662-42-2
Molecular Formula: C₂₃H₁₉ClN₂O₃
Molecular Weight: 406.86
Catalog: Signaling Pathways GPCR/G Protein Leukotriene Receptor
Create Date: 2021-05-06 20:16:45
Modify Date: 2024-01-09 18:27:18
SR2640 (hydrochloride) is a potent and selective competitive leukotriene D4/leukotriene E4 antagonist. SR2640 can be used for researching the role of leukotrienes in human asthma[1].

Name	SR 2640 hydrochloride
Synonyms	2-{[3-(2-Quinolinylmethoxy)phenyl]amino}benzoic acid hydrochloride (1:1) 2-{[3-(Quinolin-2-ylmethoxy)phenyl]amino}benzoic acid hydrochloride (1:1) Benzoic acid, 2-[[3-(2-quinolinylmethoxy)phenyl]amino]-, hydrochloride (1:1) MFCD04971976

Description	SR2640 (hydrochloride) is a potent and selective competitive leukotriene D4/leukotriene E4 antagonist. SR2640 can be used for researching the role of leukotrienes in human asthma[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
Target	LTD4 and LTE4[1]
In Vivo	SR2640 inhibits the LTD 4-induced contractions of guinea-pig ileum in a concentration-dependent manner, with an IC50 of 3 nM[1]. SR2640 (1 mg/kg; IV; single dosage) specifically prevents the contractile responses of guinea-pig ileum and trachea to LTD4 and LTE4[1]. Animal Model: Guinea pigs (injected with LTD4 and LTE4)[1] Dosage: 1 mg/kg Administration: IV; single dosage Result: Specifically prevented the contractile responses of guinea-pig ileum and trachea to LTD4 and LTE4.
References	[1]. Ahnfelt-Rønne I, Kirstein D, Kaergaard-Nielsen C. A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur J Pharmacol. 1988;155(1-2):117-128.