SR 2640 hydrochloride

Modify Date: 2024-01-09 18:27:18

SR 2640 hydrochloride Structure
SR 2640 hydrochloride structure
Common Name SR 2640 hydrochloride
CAS Number 146662-42-2 Molecular Weight 406.86
Density N/A Boiling Point N/A
Molecular Formula C23H19ClN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SR 2640 hydrochloride


SR2640 (hydrochloride) is a potent and selective competitive leukotriene D4/leukotriene E4 antagonist. SR2640 can be used for researching the role of leukotrienes in human asthma[1].

 Names

Name SR 2640 hydrochloride
Synonym More Synonyms

 SR 2640 hydrochloride Biological Activity

Description SR2640 (hydrochloride) is a potent and selective competitive leukotriene D4/leukotriene E4 antagonist. SR2640 can be used for researching the role of leukotrienes in human asthma[1].
Related Catalog
Target

LTD4 and LTE4[1]

In Vivo SR2640 inhibits the LTD 4-induced contractions of guinea-pig ileum in a concentration-dependent manner, with an IC50 of 3 nM[1]. SR2640 (1 mg/kg; IV; single dosage) specifically prevents the contractile responses of guinea-pig ileum and trachea to LTD4 and LTE4[1]. Animal Model: Guinea pigs (injected with LTD4 and LTE4)[1] Dosage: 1 mg/kg Administration: IV; single dosage Result: Specifically prevented the contractile responses of guinea-pig ileum and trachea to LTD4 and LTE4.
References

[1]. Ahnfelt-Rønne I, Kirstein D, Kaergaard-Nielsen C. A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur J Pharmacol. 1988;155(1-2):117-128.

 Chemical & Physical Properties

Molecular Formula C23H19ClN2O3
Molecular Weight 406.86
Exact Mass 406.108429

 Synonyms

2-{[3-(2-Quinolinylmethoxy)phenyl]amino}benzoic acid hydrochloride (1:1)
2-{[3-(Quinolin-2-ylmethoxy)phenyl]amino}benzoic acid hydrochloride (1:1)
Benzoic acid, 2-[[3-(2-quinolinylmethoxy)phenyl]amino]-, hydrochloride (1:1)
MFCD04971976
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