383907-47-9

383907-47-9 structure

Name: DA 3003-2
Chemical Name: DA-3003-2
CAS Number: 383907-47-9
Molecular Formula: C₁₅H₁₆ClN₃O₃
Molecular Weight: 321.759
Catalog: Research Areas Cancer
Create Date: 2021-05-14 22:19:37
Modify Date: 2024-04-07 17:09:10
DA 3003-2 is a potent and selectively Cdc25 inhibitor. DA 3003-2 shows antiproliferative activity. DA 3003-2 induces cell cycle arrest at the G2/M phase and increases the expression of P-tyr15 Cdc2. DA 3003-2 has the potential for the research of prostate cancer[1].

Name	DA-3003-2
Synonyms	7-Chloro-6-{[2-(4-morpholinyl)ethyl]amino}-5,8-quinolinedione DA-3003-2 7-chloro-6-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione 5,8-Quinolinedione, 7-chloro-6-[[2-(4-morpholinyl)ethyl]amino]-

Description	DA 3003-2 is a potent and selectively Cdc25 inhibitor. DA 3003-2 shows antiproliferative activity. DA 3003-2 induces cell cycle arrest at the G2/M phase and increases the expression of P-tyr15 Cdc2. DA 3003-2 has the potential for the research of prostate cancer[1].
Related Catalog	Research Areas >> Cancer
In Vitro	DA 3003-2 (0.3-30 µM; 48 h) 在 PC-3 细胞中显示出抗增殖活性，IC50 值为 5 µM[1]。 DA 3003-2 (5, 10 µM; 24, 1 h) 诱导细胞周期停滞在 G2/M 期并增加 PC-3 细胞中 P-tyr15 Cdc2 的表达[ 1]。 Cell Cytotoxicity Assay[1] Cell Line: PC-3 cells Concentration: 0.3-30 µM Incubation Time: 48 h Result: Showed antiproliferative efficacy in a dose-dependent manner with an IC50 value of 5 µM. Cell Cycle Analysis[1] Cell Line: PC-3 cells Concentration: 5, 10 µM Incubation Time: 24 h Result: Induced cell cycle arrest at G2/M phase. Western Blot Analysis[1] Cell Line: PC-3 cells Concentration: 5, 10 µM Incubation Time: 1 h Result: Increased the expression of P-tyr15 Cdc2.
References	[1]. Nemoto K. G2/M accumulation in prostate cancer cell line PC-3 is induced by Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino) quinoline-5, 8-dione (DA 3003-2). Exp Ther Med. 2010 Jul;1(4):647-650.