DA 3003-2
Modify Date: 2024-04-07 17:09:10
DA 3003-2 structure
|
Common Name | DA 3003-2 | ||
|---|---|---|---|---|
| CAS Number | 383907-47-9 | Molecular Weight | 321.759 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 478.8±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H16ClN3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 243.4±28.7 °C | |
Use of DA 3003-2DA 3003-2 is a potent and selectively Cdc25 inhibitor. DA 3003-2 shows antiproliferative activity. DA 3003-2 induces cell cycle arrest at the G2/M phase and increases the expression of P-tyr15 Cdc2. DA 3003-2 has the potential for the research of prostate cancer[1]. |
| Name | DA-3003-2 |
|---|---|
| Synonym | More Synonyms |
| Description | DA 3003-2 is a potent and selectively Cdc25 inhibitor. DA 3003-2 shows antiproliferative activity. DA 3003-2 induces cell cycle arrest at the G2/M phase and increases the expression of P-tyr15 Cdc2. DA 3003-2 has the potential for the research of prostate cancer[1]. |
|---|---|
| Related Catalog | |
| In Vitro | DA 3003-2 (0.3-30 µM; 48 h) 在 PC-3 细胞中显示出抗增殖活性，IC50 值为 5 µM[1]。 DA 3003-2 (5, 10 µM; 24, 1 h) 诱导细胞周期停滞在 G2/M 期并增加 PC-3 细胞中 P-tyr15 Cdc2 的表达[ 1]。 Cell Cytotoxicity Assay[1] Cell Line: PC-3 cells Concentration: 0.3-30 µM Incubation Time: 48 h Result: Showed antiproliferative efficacy in a dose-dependent manner with an IC50 value of 5 µM. Cell Cycle Analysis[1] Cell Line: PC-3 cells Concentration: 5, 10 µM Incubation Time: 24 h Result: Induced cell cycle arrest at G2/M phase. Western Blot Analysis[1] Cell Line: PC-3 cells Concentration: 5, 10 µM Incubation Time: 1 h Result: Increased the expression of P-tyr15 Cdc2. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 478.8±45.0 °C at 760 mmHg |
| Molecular Formula | C15H16ClN3O3 |
| Molecular Weight | 321.759 |
| Flash Point | 243.4±28.7 °C |
| Exact Mass | 321.088013 |
| LogP | 0.33 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.626 |
| 7-Chloro-6-{[2-(4-morpholinyl)ethyl]amino}-5,8-quinolinedione |
| DA-3003-2 |
| 7-chloro-6-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione |
| 5,8-Quinolinedione, 7-chloro-6-[[2-(4-morpholinyl)ethyl]amino]- |