581098-48-8

581098-48-8 structure

Name: p38 MAP Kinase Inhibitor III
Chemical Name: (S)-p38 MAP Kinase Inhibitor III
CAS Number: 581098-48-8
Molecular Formula: C₂₃H₂₁FN₄S
Molecular Weight: 404.503
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2021-05-16 09:33:27
Modify Date: 2025-08-25 18:32:19
p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an 50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with 50 values of 0.37 μM and 0.044 μM, respectively[1].

Name	(S)-p38 MAP Kinase Inhibitor III
Synonyms	(S)-p38 MAPK Inhibitor III 2-Pyridinamine, 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]- 4-[5-(4-Fluorophenyl)-2-(methylsulfanyl)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamine

Description	p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an 50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with 50 values of 0.37 μM and 0.044 μM, respectively[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
Target	p38 MAP kinase:0.9 μM (IC50)
References	[1]. Stefan A Laufer, et al. Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44.