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909664-41-1

909664-41-1 structure
909664-41-1 structure
  • Name: BPU-11
  • Chemical Name: BPU-11
  • CAS Number: 909664-41-1
  • Molecular Formula: C32H31N5O
  • Molecular Weight: 501.62144
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel HCN Channel
  • Create Date: 2021-05-21 17:50:00
  • Modify Date: 2023-01-11 17:44:21
  • BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease[1].

Name BPU-11
Description BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease[1].
Related Catalog
In Vitro BPU-11 (100 μM) 消除了 HCN4 cAMP 诱导的 V1/2 位移,k1/2 为 0.42 μM[1]。 BPU (100 和 200 μM) 是 HCN4 亚型特异性的,对 HEK293T 细胞中表达的 HCN2 通道无影响[1]。
References

[1]. Lolicato M, et al. Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nat Chem Biol. 2014 Jun;10(6):457-62.  

Molecular Formula C32H31N5O
Molecular Weight 501.62144