BPU-11

Modify Date: 2024-09-17 20:26:15

BPU-11 Structure
BPU-11 structure
Common Name BPU-11
CAS Number 909664-41-1 Molecular Weight 501.62144
Density N/A Boiling Point N/A
Molecular Formula C32H31N5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BPU-11


BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease[1].

 Names

Name BPU-11

 BPU-11 Biological Activity

Description BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease[1].
Related Catalog
In Vitro BPU-11 (100 μM) 消除了 HCN4 cAMP 诱导的 V1/2 位移,k1/2 为 0.42 μM[1]。 BPU (100 和 200 μM) 是 HCN4 亚型特异性的,对 HEK293T 细胞中表达的 HCN2 通道无影响[1]。
References

[1]. Lolicato M, et al. Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nat Chem Biol. 2014 Jun;10(6):457-62.  

 Chemical & Physical Properties

Molecular Formula C32H31N5O
Molecular Weight 501.62144
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