1246833-81-7

1246833-81-7 structure

Name: Naftifine-d3 (hydrochloride)
Chemical Name: Naftifine-d3 (hydrochloride)
CAS Number: 1246833-81-7
Molecular Formula: C₂₁H₁₉D₃ClN
Molecular Weight: 326.878
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2021-06-08 08:13:32
Modify Date: 2024-01-23 19:19:47
Naftifine-d3 hydrochloride is the deuterium labeled Naftifine hydrochloride. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition[1].

Name	Naftifine-d3 (hydrochloride)
Synonyms	Naftifine-d3 (hydrochloride) (2E)-N-(2H3)Methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine hydrochloride (1:1) 1-Naphthalenemethanamine, N-(methyl-d3)-N-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride (1:1)

Description	Naftifine-d3 hydrochloride is the deuterium labeled Naftifine hydrochloride. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Georgopoulos, A., et al., In vitro activity of naftifine, a new antifungal agent. Antimicrob Agents Chemother, 1981. 19(3): p. 386-9. [3]. Ryder, N.S., G. Seidl, and P.F. Troke, Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans. Antimicrob Agents Chemother, 1984. 25(4): p. 483-7. [4]. Parish, L.C., et al., A double-blind, randomized, vehicle-controlled study evaluating the efficacy and safety of naftifine 2% cream in tinea cruris. J Drugs Dermatol, 2011. 10(10): p. 1142-7. [5]. Gupta, A.K., J.E. Ryder, and E.A. Cooper, Naftifine: a review. J Cutan Med Surg, 2008. 12(2): p. 51-8.

Molecular Formula	C₂₁H₁₉D₃ClN
Molecular Weight	326.878
Exact Mass	326.162903

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