1432064-02-2

1432064-02-2 structure

Name: Trifluoperazine-d3 (hydrochloride)
Chemical Name: Trifluoperazine-d3 (hydrochloride)
CAS Number: 1432064-02-2
Molecular Formula: C₂₁H₂₃D₃Cl₂F₃N₃S
Molecular Weight: 483.44
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2021-05-06 08:58:32
Modify Date: 2024-01-18 18:48:14
Trifluoperazine-d3 (dihydrochloride) is deuterium labeled Trifluoperazine (dihydrochloride). Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].

Name	Trifluoperazine-d3 (hydrochloride)
Synonyms	10-{3-[4-(2H3)Methyl-1-piperazinyl]propyl}-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride 10H-Phenothiazine, 10-[3-[4-(methyl-d3)-1-piperazinyl]propyl]-2-(trifluoromethyl)-, hydrochloride (1:2) Trifluoperazine-d3 (hydrochloride)

Description	Trifluoperazine-d3 (dihydrochloride) is deuterium labeled Trifluoperazine (dihydrochloride). Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> CaMK Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28. [3]. Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23(1):67-70. [4]. Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004(1):CD003545. [5]. Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54(1):20-22. [6]. Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15(2):149-160.

Molecular Formula	C₂₁H₂₃D₃Cl₂F₃N₃S
Molecular Weight	483.44
Exact Mass	482.136475

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