1392208-11-5

1392208-11-5 structure

Name: Sodium 4-Phenylbutyrate-d11
Chemical Name: Sodium 4-Phenylbutyrate-d11
CAS Number: 1392208-11-5
Molecular Formula: C₁₀D₁₁NaO₂
Molecular Weight: 197.25
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2021-06-19 10:10:35
Modify Date: 2024-01-30 17:17:23
Phenylbutyrate-d11 (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[1].

Name	Sodium 4-Phenylbutyrate-d11
Synonyms	Sodium 4-(2H5)phenyl(2H6)butanoate Benzene-2,3,4,5,6-d5-butanoic-d6 acid, sodium salt (1:1) Sodium 4-Phenylbutyrate-d11

Description	Phenylbutyrate-d11 (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12. [3]. Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29. [4]. Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17.

Molecular Formula	C₁₀D₁₁NaO₂
Molecular Weight	197.25
Exact Mass	197.134720

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