2044276-17-5

2044276-17-5 structure

Name: Glycoursodeoxycholic Acid-d4 MaxSpec® Standard
Chemical Name: Glycoursodeoxycholic Acid-d4 MaxSpec® Standard
CAS Number: 2044276-17-5
Molecular Formula: C₂₆H₃₉D₄NO₅
Molecular Weight: 453.648
Catalog: Research Areas Neurological Disease
Create Date: 2021-07-21 19:45:49
Modify Date: 2024-01-24 09:06:18
Glycoursodeoxycholic acid-d4 (Ursodeoxycholylglycine-d4) is the deuterium labeled Glycoursodeoxycholic acid. Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid[1][2].

Name	Glycoursodeoxycholic Acid-d4 MaxSpec® Standard
Synonyms	N-[(3α,5β,7β)-3,7-Dihydroxy-24-oxo(2,2,4,4-2H4)cholan-24-yl]glycine Glycine, N-[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]- Glycoursodeoxycholic Acid-d4

Description	Glycoursodeoxycholic acid-d4 (Ursodeoxycholylglycine-d4) is the deuterium labeled Glycoursodeoxycholic acid. Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid[1][2].
Related Catalog	Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Vaz AR, et al. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem. 2010 Jan;112(1):56-65. [3]. Vaz AR, et al. Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration. [4]. Palmela I, et al. Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study. Front Neurosci. 2015 Mar 13;9:80.