2378640-92-5

2378640-92-5 structure

Name: ENPP1 Inhibitor C
Chemical Name: ENPP1 Inhibitor C
CAS Number: 2378640-92-5
Molecular Formula: C₁₅H₁₈N₆
Molecular Weight: 282.344
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2021-08-13 11:46:13
Modify Date: 2024-01-09 18:31:14
Enpp-1-IN-2 (Compound C) is a potent ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) inhibitor with IC50 values of 0.26, 0.48 and 2.0 μM evaluated by means of TG-mAMP, pNP-TMP, and ATP assays, respectively. TG (Tokyo Green)-mAMP: a newly synthesized sensitive ENPP1 fluorescence probe[1].

Name	ENPP1 Inhibitor C
Synonyms	ENPP1 Inhibitor C 6-(3-Aminobenzyl)-N,N,5-trimethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, 6-[(3-aminophenyl)methyl]-N,N,5-trimethyl-

Description	Enpp-1-IN-2 (Compound C) is a potent ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) inhibitor with IC50 values of 0.26, 0.48 and 2.0 μM evaluated by means of TG-mAMP, pNP-TMP, and ATP assays, respectively. TG (Tokyo Green)-mAMP: a newly synthesized sensitive ENPP1 fluorescence probe[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Target	IC50: 0.26 μM (TG-mAMP assay), 0.48 μM (pNP-TMP assay), 2.0 μM (ATP assay)[1]
References	[1]. Kawaguchi M, et al. Development of an ENPP1 Fluorescence Probe for Inhibitor Screening, Cellular Imaging, and Prognostic Assessment of Malignant Breast Cancer. J Med Chem. 2019 Oct 24;62(20):9254-9269.