652142-94-4

652142-94-4 structure

Name: STING Agonist 1a
Chemical Name: STING Agonist 1a
CAS Number: 652142-94-4
Molecular Formula: C₁₉H₁₁Cl₂N₅O
Molecular Weight: 396.229
Catalog: Signaling Pathways Immunology/Inflammation STING
Create Date: 2021-04-25 19:42:46
Modify Date: 2024-01-12 23:22:06
STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool[1].

Name	STING Agonist 1a
Synonyms	4-Chloro-1-(2-chloro-6-methoxy-3-quinolinyl)[1,2,4]triazolo[4,3-a]quinoxaline [1,2,4]Triazolo[4,3-a]quinoxaline, 4-chloro-1-(2-chloro-6-methoxy-3-quinolinyl)- MFCD03861727 STING Agonist 1a

Description	STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> STING
In Vitro	STING agonist-16 (1a) (0-100 μM, 6 h) can promote mRNA expression of IFNβ, CXCL-10 and IL-6 in a dose-dependent manner with no significant cytotoxic effect up to 100 μM in human myeloid leukemia mononuclear cells (THP1)[1]. STING agonist-16 (1a) (50 μM, 2 h) significantly induces the phosphorylation of STING, TANK-binding kinases1 (TBK1) and interferon regulatory factor 3 (IRF3) in THP1 cells[1]. STING agonist-16 (1a) activates secretory alkaline phosphatase (SEAP) in a dose-dependent manner with an EC50 value of 16.77 μM while 2'3'-cGAMP acts with an EC50 value of 9.212 μM[1].
References	[1]. Hui Hou, et al. Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screening. Bioorg Chem. 2020 Jul;100:103958.