1144043-83-3
1144043-83-3 structure
- Name: YB-0158
- Chemical Name: YB-0158
- CAS Number: 1144043-83-3
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2021-09-10 17:20:12
- Modify Date: 2024-01-11 14:16:34
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YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities[1].
| Name | YB-0158 |
|---|
| Description | YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities[1]. |
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| Related Catalog | |
| Target |
Wnt:6.2 μM (IC50) |
| In Vitro | YB-0158 (0.2 μM and 0.5 μM; 48 hours) significantly increases apoptosis in CRC cells as represented by activated Caspase-3/7 detection assays[1]. YB-0158 (0.3 μM) similarly decreases CBP recruitment at the promoter of Wnt/beta-Catenin target genes LGR5 and MYC in HT29 cells, compared with DMSO control[1]. |
| In Vivo | YB-0158 displays an EC50 (1.64 μM) in cultured MC38 cells. YB-0158 (100 mg/kg; IP; C57BL/6 mice bearing MC38 cells) shows no significant differences in primary tumor size in vivo treatments versus saline controls[2]. |
| References |
| No Any Chemical & Physical Properties |