2414276-32-5
2414276-32-5 structure
- Name: NEP
- Chemical Name: NEP
- CAS Number: 2414276-32-5
- Molecular Formula: C29H31AsN4O5S2
- Molecular Weight: 654.63
- Catalog: Research Areas Neurological Disease
- Create Date: 2021-09-13 12:51:11
- Modify Date: 2025-08-20 17:56:23
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NEP (VDP-green (NEP)) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs). NEP is exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λex/λem=430/535 nm). NEP has the potential for parkinsonism[1].
| Name | NEP |
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| Description | NEP (VDP-green (NEP)) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs). NEP is exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λex/λem=430/535 nm). NEP has the potential for parkinsonism[1]. |
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| Related Catalog | |
| In Vitro | NEP (1-30 μM; 6 hours) has no or little cytotoxicity in HepG2 and PC12 cells[1]. NEP (10 μM; 4 hours) causes the fluorescence intensity to decrease gradually in PC12 cells pretreated with 6-OHDA (0, 50, 100, and 200 μM; for 30 min)[1]. NEP contains a dithiarsolane moiety (five-membered As-S ring) as the receptor of VDPs. In the presence of VDPs, NEP displays a strong green fluorescence signal produced by the cyclic dithiarsolane cleavage and subsequent intramolecular cyclization to liberate the fluorophore. NEP maintains a reliable fluorescence response within the range of pH 7-10[1]. |
| In Vivo | NEP (10 μM; for 4 h) causes the obvious green signal in zebrafishes (4 day old)[1]. |
| References |
| Molecular Formula | C29H31AsN4O5S2 |
|---|---|
| Molecular Weight | 654.63 |