2140807-24-3
2140807-24-3 structure
- Name: Thalidomide-NH-PEG4-Ms
- Chemical Name: Thalidomide-NH-PEG4-Ms
- CAS Number: 2140807-24-3
- Molecular Formula: C22H29N3O10S
- Molecular Weight: 527.54
- Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
- Create Date: 2021-08-08 10:17:13
- Modify Date: 2024-01-19 20:22:53
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Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].
| Name | Thalidomide-NH-PEG4-Ms |
|---|
| Description | Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1]. |
|---|---|
| Related Catalog | |
| Target |
Cereblon |
| In Vitro | XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1]. |
| References |
| Molecular Formula | C22H29N3O10S |
|---|---|
| Molecular Weight | 527.54 |
| Hazard Codes | Xi |
|---|