Thalidomide-NH-PEG4-Ms

Modify Date: 2024-01-19 20:22:53

Thalidomide-NH-PEG4-Ms structure	Common Name	Thalidomide-NH-PEG4-Ms
	CAS Number	2140807-24-3	Molecular Weight	527.54
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₉N₃O₁₀S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide-NH-PEG4-Ms

Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].

Name	Thalidomide-NH-PEG4-Ms

Description	Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].
References	[1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.

Molecular Formula	C₂₂H₂₉N₃O₁₀S
Molecular Weight	527.54

Hazard Codes	Xi

DC Chemicals Limited
China
Product Name: Thalidomide-NH-PEG4-Ms
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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