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  • DC Chemicals Limited
  • China
  • Product Name: L82-G17
  • Price: $850.0/100mg $1500.0/250mg $3000.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

92285-87-5

92285-87-5 structure
92285-87-5 structure
  • Name: L82-G17
  • Chemical Name: 4-Chloro-5-[(2Z)-2-(3-hydroxybenzylidene)hydrazino]-3(2H)-pyridazinone
  • CAS Number: 92285-87-5
  • Molecular Formula: C11H9ClN4O2
  • Molecular Weight: 264.668
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
  • Create Date: 2021-05-30 15:33:10
  • Modify Date: 2024-01-12 18:10:42
  • L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity[1].

Name 4-Chloro-5-[(2Z)-2-(3-hydroxybenzylidene)hydrazino]-3(2H)-pyridazinone
Synonyms 4-Chloro-5-[(2Z)-2-(3-hydroxybenzylidene)hydrazino]-3(2H)-pyridazinone
Benzaldehyde, 3-hydroxy-, 1-[2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone]
4-Chloro-5-[(2Z)-2-(3-hydroxybenzylidene)hydrazino]pyridazin-3(2H)-one
Description L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity[1].
Related Catalog
In Vitro L82-G17 (200 μM, 30 min) has selective uncompetitive inhibitory effect for LigI[1]. L82-G17 (0-100 μM) increases LigI binding to non-ligatable nicked DNA binding[1]. L82-G17 inhibits step 3 of the ligation reaction, phosphodiester bond formation[1]. L82-G17 (0-100 μM) inhibits DNA synthesis, cell viability and s induces DNA damage[1]. Cell Viability Assay[1] Cell Line: HeLa cells Concentration: 0-30 μM Incubation Time: 5 days Result: Reduced cell number by about 70% at 20 μM. Cell Proliferation Assay[1] Cell Line: CH12F3 WT and CH12F3Δ/Δ cells Concentration: 0-100 μM Incubation Time: 72 h Result: Had great effect on the proliferation and survival of the parental CH12F3 cells.
Density 1.5±0.1 g/cm3
Molecular Formula C11H9ClN4O2
Molecular Weight 264.668
Exact Mass 264.041412
LogP 0.99
Index of Refraction 1.685