L82-G17
Modify Date: 2024-01-12 18:10:42
L82-G17 structure
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Common Name | L82-G17 | ||
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| CAS Number | 92285-87-5 | Molecular Weight | 264.668 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C11H9ClN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of L82-G17L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity[1]. |
| Name | 4-Chloro-5-[(2Z)-2-(3-hydroxybenzylidene)hydrazino]-3(2H)-pyridazinone |
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| Synonym | More Synonyms |
| Description | L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity[1]. |
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| Related Catalog | |
| In Vitro | L82-G17 (200 μM, 30 min) has selective uncompetitive inhibitory effect for LigI[1]. L82-G17 (0-100 μM) increases LigI binding to non-ligatable nicked DNA binding[1]. L82-G17 inhibits step 3 of the ligation reaction, phosphodiester bond formation[1]. L82-G17 (0-100 μM) inhibits DNA synthesis, cell viability and s induces DNA damage[1]. Cell Viability Assay[1] Cell Line: HeLa cells Concentration: 0-30 μM Incubation Time: 5 days Result: Reduced cell number by about 70% at 20 μM. Cell Proliferation Assay[1] Cell Line: CH12F3 WT and CH12F3Δ/Δ cells Concentration: 0-100 μM Incubation Time: 72 h Result: Had great effect on the proliferation and survival of the parental CH12F3 cells. |
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C11H9ClN4O2 |
| Molecular Weight | 264.668 |
| Exact Mass | 264.041412 |
| LogP | 0.99 |
| Index of Refraction | 1.685 |
| 4-Chloro-5-[(2Z)-2-(3-hydroxybenzylidene)hydrazino]-3(2H)-pyridazinone |
| Benzaldehyde, 3-hydroxy-, 1-[2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone] |
| 4-Chloro-5-[(2Z)-2-(3-hydroxybenzylidene)hydrazino]pyridazin-3(2H)-one |