109163-69-1

109163-69-1 structure

Name: Caffeoyltryptophan
Chemical Name: N-Caffeoyltryptophan
CAS Number: 109163-69-1
Molecular Formula: C₂₀H₁₈N₂O₅
Molecular Weight: 366.367
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2021-09-18 11:47:26
Modify Date: 2022-07-16 15:18:22
Caffeoyltryptophan is a competitive PTP1B inhibitor, with an IC50 of 16.99 μM. Caffeoyltryptophan can also inhibit α-glucosidase, linoleic acid peroxidation and haemolysis. Caffeoyltryptophan can be used for the research of type 2 diabetes[1].

Name	N-Caffeoyltryptophan
Synonyms	L-Tryptophan, N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]- N-[(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]-L-tryptophan

Description	Caffeoyltryptophan is a competitive PTP1B inhibitor, with an IC50 of 16.99 μM. Caffeoyltryptophan can also inhibit α-glucosidase, linoleic acid peroxidation and haemolysis. Caffeoyltryptophan can be used for the research of type 2 diabetes[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Metabolic Disease
References	[1]. Ha MT, et, al. PTP1B and α-glucosidase inhibitory activities of the chemical constituents from Hedera rhombea fruits: Kinetic analysis and molecular docking simulation. Phytochemistry. 2022 May:197:113100. [2]. Ohnishi M, et, al. Inhibition in vitro linoleic acid peroxidation and haemolysis by caffeoyltryptophan. Phytochemistry. 1998 Apr;47(7):1215-8.