Name | 3-(2-Aminoethoxy) Thalidomide |
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Synonyms |
4-(2-Aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)- |
Description | Thalidomide 4'-ether-alkylC2-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. |
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Related Catalog | |
Target |
Cereblon |
In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 612.1±55.0 °C at 760 mmHg |
Molecular Formula | C15H15N3O5 |
Molecular Weight | 317.297 |
Flash Point | 324.0±31.5 °C |
Exact Mass | 317.101166 |
LogP | -0.79 |
Vapour Pressure | 0.0±1.8 mmHg at 25°C |
Index of Refraction | 1.634 |
Hazard Codes | Xi |
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