36531-26-7
36531-26-7 structure
- Name: Oxantel
- Chemical Name: 3-[(E)-2-(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol
- CAS Number: 36531-26-7
- Molecular Formula: C13H16N2O
- Molecular Weight: 216.27900
- Catalog: API Antiparasitic drug Anthelmintic
- Create Date: 2018-02-21 08:00:00
- Modify Date: 2024-01-02 10:19:53
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Oxantel (CP-14445), a m-oxyphenol derivative of Pyrantel (HY-12641), is a N-subtype AChR agonist. Oxantel is an anthelmintic, with excellent trichuricidal properties[1][2].
| Name | 3-[(E)-2-(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol |
|---|---|
| Synonyms |
UNII-94AJJ30D9E
OXANTEL Oxantelum |
| Description | Oxantel (CP-14445), a m-oxyphenol derivative of Pyrantel (HY-12641), is a N-subtype AChR agonist. Oxantel is an anthelmintic, with excellent trichuricidal properties[1][2]. |
|---|---|
| Related Catalog | |
| Target |
nAChR[1][2] |
| In Vitro | Oxantel ( 0.015-600 µg/mL; 24-72 hours) reduces the viability of T. muris[1]. Cell Viability Assay Cell Line: T. muris Concentration: 0.015 µg/mL, 0.3 µg/mL, 0.6 µg/mL, 4.66 µg/mL, 9.375 µg/mL, 150 µg/mL, 600 µg/mL Incubation Time: 24 hours, 48 hours, 72 hours Result: Resulted in strongly reduced viabilities; resulted in strongly reduced viabilities within 24 hours but did not kill the worms. |
| In Vivo | Oxantel (1-10 mg/kg; i.p.) displays a high activity against T. muris in vivo, with an EC50 of 4.71 mg/kg[1]. Oxantel (10 mg/kg; i.p.) exhibits a worm burden reduction (WBR) of 92.5% and worm expulsion rate (WER) of 88.4% for T. muris[1]. Animal Model: 4 week-old female C57BL/10 mice and 3 week-old male[1] Dosage: 1 mg/kg, 2.5 mg/kg, 5 mg/kg, 10 mg/kg Administration: Intraperitoneal injection Result: Inhibited T. muris in vivo. |
| References |
| Density | 1.09g/cm3 |
|---|---|
| Boiling Point | 383.1ºC at 760mmHg |
| Molecular Formula | C13H16N2O |
| Molecular Weight | 216.27900 |
| Flash Point | 185.5ºC |
| Exact Mass | 216.12600 |
| PSA | 35.83000 |
| LogP | 1.51290 |
| Index of Refraction | 1.575 |
| HS Code | 2933599090 |
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| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |