64761-48-4
64761-48-4 structure
- Name: Harringtonolide
- Chemical Name: (11S,12R,13S,19R)-8,19-Dimethyl-14,17-dioxahexacyclo[13.3.1.01,11.04,10.09,13.012,16]nonadeca-4,7,9-triene-6,18-dione
- CAS Number: 64761-48-4
- Molecular Formula: C19H18O4
- Molecular Weight: 310.344
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FAK
- Create Date: 2021-09-10 16:50:13
- Modify Date: 2024-01-10 17:40:44
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Harringtonolide is a potent RACK1 inhibitor (IC50=39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities[1].
| Name | (11S,12R,13S,19R)-8,19-Dimethyl-14,17-dioxahexacyclo[13.3.1.01,11.04,10.09,13.012,16]nonadeca-4,7,9-triene-6,18-dione |
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| Synonyms |
1H-3,10a-Methano-2,4-dioxacyclohepta[bc]cyclopent[jk]acenaphthylene-1,7(3H)-dione, 2a,4a,9,10,10b,10c-hexahydro-5,11-dimethyl-, (4aS,10bS,10cR,11R)-
(11S,12R,13S,19R)-8,19-Dimethyl-14,17-dioxahexacyclo[13.3.1.01,11.04,10.09,13.012,16]nonadeca-4,7,9-triene-6,18-dione |
| Description | Harringtonolide is a potent RACK1 inhibitor (IC50=39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities[1]. |
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| Related Catalog | |
| Target |
IC50: 39.66 μM (RACK1) in A375 cells[1] |
| In Vitro | Harringtonolide (0-50 μM; 24 hours) exhibits good antiproliferation activity in A375 cells with IC50 of 39.66 μM[1]. Harringtonolide (0-20 μM; 1 hour) restrains the proteolysis of RACK1 by Pronase, and protects temperature-dependent degradation of RACK1[1]. Harringtonolide (0-4 μM; 24 hours) suppresses the phosphorylation of FAK dose-dependently and inhibits Src and STAT3, the downstream proteins of FAK[1]. Harringtonolide (0-4 μM; 24 hours) dose-dependently inhibits the RACK1–FAK interaction in A375 cells[1]. Cell Proliferation Assay Cell Line: A375 melanoma cells[1] Concentration: 0-50 μM Incubation Time: 24 hours Result: Showed good antiproliferation activity with IC50 of 39.66 μM. Western Blot Analysis Cell Line: A375 melanoma cells[1] Concentration: 0, 0.5, 1, 2, 4 μM Incubation Time: 24 hours Result: Suppressed the phosphorylation of FAK dose-dependently and inhibited Src and STAT3, the downstream proteins of FAK. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 605.5±55.0 °C at 760 mmHg |
| Molecular Formula | C19H18O4 |
| Molecular Weight | 310.344 |
| Flash Point | 270.5±31.5 °C |
| Exact Mass | 310.120514 |
| LogP | 1.53 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.656 |