16330-92-0

16330-92-0 structure

Name: tetrathiomolybdate
Chemical Name: tetrathiomolybdate(2−)
CAS Number: 16330-92-0
Molecular Formula: MoS₄--
Molecular Weight: 224.22000
Catalog: Research Areas Cardiovascular Disease
Create Date: 2016-08-07 17:47:01
Modify Date: 2024-01-02 12:06:29
Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. Tetrathiomolybdate has a protective effect on collagen-induced arthritis in mice. Tetrathiomolybdate also reduces blood sugar, but has no effect on mice with hereditary diabetes (db/db). Tetrathiomolybdate inhibit angiogenesis, also shows antiangiogenic effects in malignant pleural mesothelioma[1][2][3].

Name	tetrathiomolybdate(2−)

Description	Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. Tetrathiomolybdate has a protective effect on collagen-induced arthritis in mice. Tetrathiomolybdate also reduces blood sugar, but has no effect on mice with hereditary diabetes (db/db). Tetrathiomolybdate inhibit angiogenesis, also shows antiangiogenic effects in malignant pleural mesothelioma[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vivo	Tetrathiomolybdate (0.2 mg/小鼠/天; 口服; 10 周)保护小鼠免受胶原诱导的关节炎，具有预防作用[1]。 Tetrathiomolybdate (0.03 mg/mL; 加在水中，8 周)通过减少肿胀和红斑抑制小鼠胶原诱导关节炎的进展[1]。 Animal Model: Collagen-induced arthritis model in mice[1] Dosage: 0.2 mg/mouse/day or 0.03 mg/mL, added in water Administration: Oral gavage, for 10 weeks; Collagen injected at weeks 2 Result: Showed significant preventive effect and protective effect in mice.
References	[1]. Zeng C, et al. Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetes. Exp Biol Med (Maywood). 2008 Aug;233(8):1021-5.