1162-65-8

1162-65-8 structure

Name: AFLATOXIN B1
Chemical Name: aflatoxin B1
CAS Number: 1162-65-8
Molecular Formula: C₁₇H₁₂O₆
Molecular Weight: 312.274
Catalog: analytical chemistry Standard Food and cosmetics standards
Create Date: 2018-02-07 08:00:00
Modify Date: 2024-01-02 18:10:03
Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation[1][2].

Name	aflatoxin B1
Synonyms	Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR,9aS)- Aflatoxin B1 Aflatoxin B1 Crystalline (-)-Aflatoxin B1 (6aR,9aS)-4-Methoxy-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene-1,11-dione Aflatoxin B1, crystalline MFCD00869647 Aflatoxin EINECS 214-603-3

Description	Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Human Endogenous Metabolite
References	[1]. Gizachew D, et al. Aflatoxin B1 (AFB1) production by Aspergillus flavus and Aspergillus parasiticus on ground Nyjer seeds: The effect of water activity and temperature. Int J Food Microbiol. 2019 May 2;296:8-13. [2]. Aguilar F, et al. Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8586-90.

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H300 + H310 + H330-H350
Precautionary Statements	P201-P260-P264-P280-P284-P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T+,T,Xn,F
Risk Phrases	45-46-26/27/28-36-20/21/22-11-65-48/23/24/25-36/38-39/23/24/25-23/24/25
Safety Phrases	53-45-36-26-16-24-7
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS	GY1925000
Packaging Group	I