Shanghai Nianxing Industrial Co., Ltd
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GL Biochem (Shanghai) Ltd.
China
Product Name: [DGlp1,DPhe2,DTrp3,6]-LH-RH
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
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68059-94-9

68059-94-9 structure

68059-94-9 structure

Name: [DGlp1,DPhe2,DTrp3,6]-LH-RH
Chemical Name: [DGlp1,DPhe2,DTrp3,6]-LH-RH
CAS Number: 68059-94-9
Molecular Formula: C₆₇H₈₄N₁₆O₁₃
Molecular Weight: 1321.48000
Catalog: Signaling Pathways GPCR/G Protein GNRH Receptor
Create Date: 2018-12-28 11:18:43
Modify Date: 2025-08-27 08:33:28
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist[1].

Name	[DGlp1,DPhe2,DTrp3,6]-LH-RH
Synonyms	D-pglu1,D-phe2,D-trp3,6-luteinizing*hormone relea pglu(1)-phe(2)-trp(3,6)-lhr LHRH,pGlu(1)-Phe(2)-Trp(3,6) [D-PGLU1,D-PHE2,D-TRP3,6]-LH-RH [D-PYR1,D-PHE2,D-TRP3,6]-LH-RH (HUMAN) (D-PYR1,D-PHE2,D-TRP3,6)-LHRH DGLP-DPHE-DTRP-SER-TYR-DTRP-LEU-ARG-PRO-GLY-NH2 [D-PYROGLU1,D-PHE2,D-TRP3,6]-LH-RH (D-Pyr1,D-Phe2,D-Trp3

Description	[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Research Areas >> Endocrinology
Target	GnRH receptor[1]
In Vitro	[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (1 μM), together with LH-RH and FSH, blocks the inhibition of FSH-induced steroidogenesis in rat ovary granulosa cells[3].
In Vivo	[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (1.25 and 2.5 mg, subcutaneous injection, b.i.d, for 7 days) prolongs pregnancy in rats[1]. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (250 μg) inhibits ovulation by 100% in rats[2].

Molecular Formula	C₆₇H₈₄N₁₆O₁₃
Molecular Weight	1321.48000
Exact Mass	1320.64000
PSA	459.24000
LogP	4.47690

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R60
Safety Phrases	53-22-36/37/39-45
RIDADR	NONH for all modes of transport

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