Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Toddalolactone
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: Toddalolactone
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Toddalolactone
Price: ￥1178.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: toddalolactone
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: toddalolactone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

483-90-9

483-90-9 structure

483-90-9 structure

Name: Toddalolactone
Chemical Name: 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxychromen-2-one
CAS Number: 483-90-9
Molecular Formula: C₁₆H₂₀O₆
Molecular Weight: 308.326
Catalog: Biochemical Plant extracts
Create Date: 2018-09-26 12:51:01
Modify Date: 2024-01-02 10:10:31
Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM[1].

Name	6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxychromen-2-one
Synonyms	2H-1-Benzopyran-2-one, 6-(2,3-dihydroxy-3-methylbutyl)-5,7-dimethoxy- 6-[(2r)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxy-2h-chromen-2-one 6-(2,3-Dihydroxy-3-methylbutyl)-5,7-dimethoxy-2H-chromen-2-one (+)-toddalolactone Toddaline Toddalolactone

Description	Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1 Research Areas >> Cardiovascular Disease
In Vitro	Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1[1].
References	[1]. Yu B, et al. Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum. Front Pharmacol. 2017 Jul 21;8:489.

Density	1.3±0.1 g/cm3
Boiling Point	530.0±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₂₀O₆
Molecular Weight	308.326
Flash Point	195.5±23.6 °C
Exact Mass	308.125977
PSA	89.13000
LogP	0.88
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.569
Storage condition	2-8C

137764-14-8 structure

137764-14-8

~15%

77636-08-9 structure

77636-08-9

483-90-9 structure

483-90-9

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 13 p. 1681 - 1684

Precursor 1
137764-14-8
DownStream 0