Toddalolactone

Modify Date: 2025-08-20 10:13:25

Toddalolactone Structure
Toddalolactone structure
Common Name Toddalolactone
CAS Number 483-90-9 Molecular Weight 308.326
Density 1.3±0.1 g/cm3 Boiling Point 530.0±50.0 °C at 760 mmHg
Molecular Formula C16H20O6 Melting Point N/A
MSDS N/A Flash Point 195.5±23.6 °C

 Use of Toddalolactone


Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM[1].

 Names

Name 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxychromen-2-one
Synonym More Synonyms

 Toddalolactone Biological Activity

Description Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM[1].
Related Catalog
In Vitro Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1[1].
References

[1]. Yu B, et al. Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum. Front Pharmacol. 2017 Jul 21;8:489.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 530.0±50.0 °C at 760 mmHg
Molecular Formula C16H20O6
Molecular Weight 308.326
Flash Point 195.5±23.6 °C
Exact Mass 308.125977
PSA 89.13000
LogP 0.88
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.569
Storage condition 2-8C

 Synthetic Route

~15%

Toddalolactone Structure

Toddalolactone

CAS#:483-90-9

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 13 p. 1681 - 1684

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

2H-1-Benzopyran-2-one, 6-(2,3-dihydroxy-3-methylbutyl)-5,7-dimethoxy-
6-[(2r)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxy-2h-chromen-2-one
6-(2,3-Dihydroxy-3-methylbutyl)-5,7-dimethoxy-2H-chromen-2-one
(+)-toddalolactone
Toddaline
Toddalolactone
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here





Get all suppliers and price by the below link:

Toddalolactone suppliers


Price: ¥1190/5 mg

Reference only. check more Toddalolactone price