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153-98-0

153-98-0 structure
153-98-0 structure
Name Serotonin hydrochloride
Synonyms 3-(2-aminoethyl)-1H-indol-5-ol,hydrochloride
3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride
3-(2-Aminoethyl)-5-hydroxyindole hydrochloride,5-HT,5-Hydroxytryptamine hydrochloride
5-hydroxytryptamine hydrochloride
Serotonin HCl
1H-Indol-5-ol, 3-(2-aminoethyl)-, hydrochloride (1:1)
3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride (1:1)
EINECS 244-464-4
MFCD00012686
5-Hydroxytryptamine HCl
Description Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
Related Catalog
Target

5-HT receptor[1] Ki: 44 μM (COMT)[1]

In Vitro Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki= 44 μM). Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT[1].
In Vivo Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001)[1]. A significant increase in colonic 5-HT content is observed in IL-13-/- mice receiving Serotonin hydrochloride compare to IL-13-/- receiving vehicle following induction of DSS colitis[2].
Cell Assay For macrophage culture, peritoneal cavity cells are collected from WT and IL-13-/- mice with or without dextran sodium sulfate (DSS) treatment and cultured. Cells are plated at a concentration of 3.0×106 cells per millilitre, and treated with either lipopolysaccharides (LPS); (100 ng/mL) or Serotonin hydrochloride (10-10 M) for 24 hours. The culture supernatant are collected and stored in -80°C until determination of cytokine levels using protein array system[2].
Animal Admin Dextran sodium sulfate (DSS) colitis is induced by orally administering 5% DSS in drinking water for 5 days. In a separate experiment, IL-13-/- mice are injected subcutaneously with 100 mg/kg of Serotonin hydrochloride (5-HTP) twice daily for 8 days beginning 3 days prior to induction of DSS colitis; whereas, the control IL-13-/- mice receive saline as vehicle. Animals are anaesthetized prior to euthanization via cervical dislocation at the conclusion of each experiment or if they reach a predetermined end point (ie, loss of ≥20% body weight and/or significant deterioration of body condition)[2].
References

[1]. Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13;8:25.

[2]. Shajib MS, et al. Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. PLoS One. 2013 Aug 28;8(8):e72774.
Boiling Point 416.1ºC at 760 mmHg
Melting Point 149-154 °C(lit.)
Molecular Formula C10H13ClN2O
Molecular Weight 212.676
Flash Point 205.4ºC
Exact Mass 212.071640
PSA 62.04000
LogP 2.87700
Vapour Pressure 1.63E-07mmHg at 25°C
Storage condition 2-8°C
Stability Stable, but light sensitive and hygroscopic. Incompatible with strong oxidizing agents.
Water Solubility soluble
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H315-H319-H332-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22;R36/37/38
Safety Phrases S22-S26-S36
RIDADR UN2811
WGK Germany 3
RTECS NM2571000
Packaging Group III
Hazard Class 6.1
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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