611-40-5

611-40-5 structure

Name: tectoridin
Chemical Name: tectoridin
CAS Number: 611-40-5
Molecular Formula: C₂₂H₂₂O₁₁
Molecular Weight: 462.404
Catalog: Biochemical Plant extracts
Create Date: 2018-08-25 21:59:21
Modify Date: 2024-01-02 10:19:50
Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway[1][2].

Name	tectoridin
Synonyms	4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy- Tectorigenin 7-glucoside 4',5-Dihydro-6-methoxy-7-(o-glucoside)isoflavone 5-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4-oxo-4H-chromen-7-yl β-D-glucopyranoside Shekanin tectoridin Tectoridin (7CI,8CI) 5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one

Description	Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway[1][2].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
In Vitro	Tectoridin scarcely binds to ER alpha as compared to 17beta-estradiol and genistein[2]. Tectoridin induceds potent estrogenic effects, namely recovery of the population of cells in the S-phase after serum starvation, transactivation of the estrogen response element, and induction of MCF-7 cell proliferation[2]. Tectoridin induces estrogenic effect, and this effect is severely abrogated by treatment with U0126 ( MEK1/2 inhibitor). Tectoridin promotes phosphorylation of ERK1/2, but does not affect phosphorylation of ER alpha at Ser (118). It also increases cellular accumulation of cAMP[2].
References	[1]. Shim M, et al. Tectoridin from Maackia amurensis modulates both estrogen and thyroid receptors.Phytomedicine. 2014 Apr 15;21(5):602-6. [2]. Kang K, et al. Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway.Mol Cells. 2009 Mar 31;27(3):351-7.

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyph enyl)-6-methoxy-

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,186,1968

Hazard Codes	C
RIDADR	NONH for all modes of transport
RTECS	DJ3090000
HS Code	29389090

Precursor 0
DownStream 1
2345-17-7