tectoridin

Modify Date: 2024-01-02 10:19:50

tectoridin structure	Common Name	tectoridin
	CAS Number	611-40-5	Molecular Weight	462.404
	Density	1.6±0.1 g/cm3	Boiling Point	798.1±60.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₂O₁₁	Melting Point	261.8-263.2ºC
	MSDS	Chinese USA	Flash Point	279.7±26.4 °C

Use of tectoridin

Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway[1][2].

Name	tectoridin
Synonym	More Synonyms

Description	Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway[1][2].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
In Vitro	Tectoridin scarcely binds to ER alpha as compared to 17beta-estradiol and genistein[2]. Tectoridin induceds potent estrogenic effects, namely recovery of the population of cells in the S-phase after serum starvation, transactivation of the estrogen response element, and induction of MCF-7 cell proliferation[2]. Tectoridin induces estrogenic effect, and this effect is severely abrogated by treatment with U0126 ( MEK1/2 inhibitor). Tectoridin promotes phosphorylation of ERK1/2, but does not affect phosphorylation of ER alpha at Ser (118). It also increases cellular accumulation of cAMP[2].
References	[1]. Shim M, et al. Tectoridin from Maackia amurensis modulates both estrogen and thyroid receptors.Phytomedicine. 2014 Apr 15;21(5):602-6. [2]. Kang K, et al. Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway.Mol Cells. 2009 Mar 31;27(3):351-7.

Density	1.6±0.1 g/cm3
Boiling Point	798.1±60.0 °C at 760 mmHg
Melting Point	261.8-263.2ºC
Molecular Formula	C₂₂H₂₂O₁₁
Molecular Weight	462.404
Flash Point	279.7±26.4 °C
Exact Mass	462.116211
PSA	179.28000
LogP	0.29
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.695

tectoridin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3090000

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyph enyl)-6-methoxy-

CAS REGISTRY NUMBER :: 611-40-5

BEILSTEIN REFERENCE NO. :: 0068384

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H22-O11

MOLECULAR WEIGHT :: 462.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4200 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,186,1968

Hazard Codes	C
RIDADR	NONH for all modes of transport
RTECS	DJ3090000
HS Code	29389090

Precursor 0
DownStream 1
CAS#:2345-17-7 Irisolidone

Tectorigenin inhibits IFN-gamma/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells.

Arch. Pharm. Res. 31(11) , 1447-56, (2008)

Tectorigenin (Tg) and tectoridin (Td) are the major compounds isolated from the rhizomes of iridaceous plant Belamcanda chinensis which is well known as a chinese traditional medicine for the treatmen...

Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway.

Mol. Cells 27(3) , 351-7, (2009)

Phytoestrogens are the natural compounds isolated from plants, which are structurally similar to animal estrogen, 17beta-estradiol. Tectoridin, a major isoflavone isolated from the rhizome of Belamcan...

Microbial transformation and bioactivation of isoflavones from Pueraria flowers by human intestinal bacterial strains.

J. Nat. Med. 63(3) , 254-60, (2009)

The flowers from Pueraria, which are called Puerariae Flos, have been used since ancient times for recovery from alcohol intoxication. We elucidated the microbial transformation of the main isoflavone...

4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-

Tectorigenin 7-glucoside

4',5-Dihydro-6-methoxy-7-(o-glucoside)isoflavone

5-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4-oxo-4H-chromen-7-yl β-D-glucopyranoside

Shekanin

tectoridin

Tectoridin (7CI,8CI)

5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: tectoridin
Price: Check
Purity: 98.0%
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BioBioPha
China
Product Name: tectoridin
Price: ￥Inquiry/5mg
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: tectoridin
Price: ￥448.0/20mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Tectoridin
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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tectoridin

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