110140-89-1

110140-89-1 structure

Name: Ridogrel
Chemical Name: Pentanoic acid, 5-[[(E)-[3-pyridinyl[3-(trifluoromethyl)phenyl]methylene]amino]oxy]
CAS Number: 110140-89-1
Molecular Formula: C₁₈H₁₇F₃N₂O₃
Molecular Weight: 366.33400
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2018-08-08 19:13:56
Modify Date: 2024-01-02 15:03:17
Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities[1][2][3].

Name	Pentanoic acid, 5-[[(E)-[3-pyridinyl[3-(trifluoromethyl)phenyl]methylene]amino]oxy]
Synonyms	ridogrel

Description	Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
In Vitro	In rats, R 68 070 (1.25 mg/kg orally, -2 h) singly prolongs tail bleeding times as much as a combination of TXA2 synthetase inhibition (dazoxiben 10 mg/kg) and TXA2/prostaglandin endoperoxide receptor blockade (BM 13177 40 mg/kg). In dogs, the compound reduces coronary thrombosis induced by electrical damage (1.25 mg/kg i.v.) and prevents the evolution of occlusion/reperfusion-induced arrhythmias into ventricular fibrillation (2.5 mg/kg i.v.)[2.
References	[1]. De Clerck F, et al. R 68 070: thromboxane A2 synthetase inhibition and thromboxane A2/prostaglandin endoperoxide receptor blockade combined in one molecule--II. Pharmacological effects in vivo and ex vivo. Thromb Haemost. 1989;61(1):43-49. [2]. Di Perri T, et al. Ridogrel, una nuova molecula antiaggregante piastrinica a doppio meccanismo d'azione. Profilo farmacologico e clinico [Ridogrel, a new platelet antiaggregant molecule with a double mechanism of action. A pharmacological and clinical profile]. Recenti Prog Med. 1991;82(10):533-540. [3]. Carty E, et al. Ridogrel, a dual thromboxane synthase inhibitor and receptor antagonist: anti-inflammatory profile in inflammatory bowel disease. Aliment Pharmacol Ther. 2000;14(6):807-817.

Density	1.26g/cm3
Boiling Point	495.2ºC at 760mmHg
Molecular Formula	C₁₈H₁₇F₃N₂O₃
Molecular Weight	366.33400
Flash Point	253.3ºC
Exact Mass	366.11900
PSA	71.78000
LogP	4.12430
Vapour Pressure	1.26E-10mmHg at 25°C
Index of Refraction	1.531

110169-17-0

67-66-3

~41%

110140-89-1

Literature: US4746671 A1, ;

Precursor 2
110169-17-0 67-66-3
DownStream 0