32744-80-2

32744-80-2 structure

Name: 3-Chlorogentisyl alcohol
Chemical Name: chlorogentisyl alcohol
CAS Number: 32744-80-2
Molecular Formula: C₇H₇ClO₃
Molecular Weight: 174.58200
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-02-15 06:40:36
Modify Date: 2025-08-20 13:24:10
3-Chlorogentisyl alcohol is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.74 µM, an Ki value of 0.58 µM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies[1].

Name	chlorogentisyl alcohol
Synonyms	3-Chlorgentisylalkohol 3-Chlorogentisyl alcohol 2,5-Dihydroxy-3-chlorobenzyl alcohol 2-(Hydroxymethyl)-6-chlorohydroquinone 6-Chlorogentisylalcohol 2-Chloro-6-(hydroxymethyl)-1,4-benzenediol 2-chloro-6-(hydroxymethyl)benzene-1,4-diol 3-chloro-2,5-dihydroxy benzyl alcohol AMUDOL

Description	3-Chlorogentisyl alcohol is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.74 µM, an Ki value of 0.58 µM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 0.74 µM (β-glucuronidase)[1]
In Vitro	3-Chlorogentisyl alcohol (compound 1) (20 µM; 24 h) shows antiproliferative activity in Namalwa, U266 cells[1]. Cell Proliferation Assay[1] Cell Line: Namalwa, U266 cells Concentration: 20 µM Incubation Time: 24 h Result: Showed antiproliferative activity with the viability rate of 70.40% and 94.08% in Namalwa, U266 cells, respectively.
References	[1]. YichaoGe， et al. Exploring gabosine and chlorogentisyl alcohol derivatives from a marine-derived fungus as EcGUS inhibitors with informatic assisted approaches. European Journal of Medicinal Chemistry, 2022, 114699.

35354-35-9

32744-80-2

Literature: McCorkindale,N.J. et al. Tetrahedron, 1972 , vol. 28, p. 1107 - 1111

35354-34-8

32744-80-2

Literature: McCorkindale,N.J. et al. Tetrahedron, 1972 , vol. 28, p. 1107 - 1111

1084-96-4

32744-80-2

Literature: McCorkindale,N.J. et al. Tetrahedron, 1972 , vol. 28, p. 1107 - 1111

5330-25-6

32744-80-2

Literature: McCorkindale,N.J. et al. Tetrahedron, 1972 , vol. 28, p. 1107 - 1111

32744-83-5

32744-80-2

Literature: Sequin-Frey,M.; Tamm,C. Helvetica Chimica Acta, 1971 , vol. 54, # 3 p. 851 - 861

615-67-8

32744-80-2

Literature: Sequin-Frey,M.; Tamm,C. Helvetica Chimica Acta, 1971 , vol. 54, # 3 p. 851 - 861