3-Chlorogentisyl alcohol

Modify Date: 2024-01-03 11:22:06

3-Chlorogentisyl alcohol Structure
3-Chlorogentisyl alcohol structure
Common Name 3-Chlorogentisyl alcohol
CAS Number 32744-80-2 Molecular Weight 174.58200
Density N/A Boiling Point N/A
Molecular Formula C7H7ClO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 3-Chlorogentisyl alcohol


3-Chlorogentisyl alcohol is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.74 µM, an Ki value of 0.58 µM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies[1].

 Names

Name chlorogentisyl alcohol
Synonym More Synonyms

 3-Chlorogentisyl alcohol Biological Activity

Description 3-Chlorogentisyl alcohol is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.74 µM, an Ki value of 0.58 µM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies[1].
Related Catalog
Target

IC50: 0.74 µM (β-glucuronidase)[1]

In Vitro 3-Chlorogentisyl alcohol (compound 1) (20 µM; 24 h) shows antiproliferative activity in Namalwa, U266 cells[1]. Cell Proliferation Assay[1] Cell Line: Namalwa, U266 cells Concentration: 20 µM Incubation Time: 24 h Result: Showed antiproliferative activity with the viability rate of 70.40% and 94.08% in Namalwa, U266 cells, respectively.
References

[1]. YichaoGe, et al. Exploring gabosine and chlorogentisyl alcohol derivatives from a marine-derived fungus as EcGUS inhibitors with informatic assisted approaches. European Journal of Medicinal Chemistry, 2022, 114699.

 Chemical & Physical Properties

Molecular Formula C7H7ClO3
Molecular Weight 174.58200
Exact Mass 174.00800
PSA 60.69000
LogP 1.32750

 Synonyms

3-Chlorgentisylalkohol
3-Chlorogentisyl alcohol
2,5-Dihydroxy-3-chlorobenzyl alcohol
2-(Hydroxymethyl)-6-chlorohydroquinone
6-Chlorogentisylalcohol
2-Chloro-6-(hydroxymethyl)-1,4-benzenediol
2-chloro-6-(hydroxymethyl)benzene-1,4-diol
3-chloro-2,5-dihydroxy benzyl alcohol
AMUDOL