222723-55-9

222723-55-9 structure

Name: Noladin ether
Chemical Name: 2-O-arachidonylglycerol
CAS Number: 222723-55-9
Molecular Formula: C₂₃H₄₀O₃
Molecular Weight: 364.562
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2016-01-15 21:19:47
Modify Date: 2025-09-22 12:58:21
Noladin ether is a potent and selective agonist of cannabinoid CB1 receptor, with a Ki of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception[1].

Name	2-O-arachidonylglycerol
Synonyms	2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoxy]propane-1,3-diol 2-AG ether 2-Arachidonyl Glycerol ether 2-arachidonyl glyceryl ether 1,3-Propanediol, 2-[(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yloxy]- 2-[(5Z,8Z,11Z,14Z)-5,8,11,14-Icosatetraen-1-yloxy]-1,3-propanediol 2-[(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraen-1-yloxy]propane-1,3-diol 2-AG ether HU 310 Noladin noladin ether 1,3-Propanediol, 2-[(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenyloxy]-

Description	Noladin ether is a potent and selective agonist of cannabinoid CB1 receptor, with a Ki of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	CB1:21.2 nM (Ki) CB2:>3 mM (Ki)
References	[1]. Hanus L, et, al. 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3662-5.